AIP-210 Leak Questions

R-squared is a statistical measure that indicates how well a regression model fits the data. R-squared is calculated by dividing the explained variance by the total variance. The explained variance is the amount of variation in the dependent variable that can be attributed to the independent variables. The total variance is the amount of variation in the dependent variable that can be observed in the data. R-squared ranges from 0 to 1, where 0 means no fit and 1 means perfect fit.

k-means clustering is an algorithm that should be used by the market research team to obtain groups of patients with similar unmet needs. k-means clustering is an unsupervised learning technique that partitions the data into k clusters based on the similarity of the features. The algorithm iteratively assigns each data point to the cluster with the nearest centroid and updates the centroid until convergence. k-means clustering can help identify patterns and segments in the data that may not be obvious or intuitive. References: [K-means clustering - Wikipedia], [How to Run K-Means Clustering in Python]

Hyperparameter optimization is the process of finding the optimal values for hyperparameters that control the learning process of a given algorithm. Hyperparameters are parameters that are not learned by the algorithm but are set by the user before training. Hyperparameters can affect the performance and behavior of the algorithm, such as its speed, accuracy, complexity, or generalization. Hyperparameter optimization can help improve the efficiency and effectiveness of the algorithm by tuning its hyperparameters to achieve the best results.

A false negative is an error where a positive case (belonging to the target class) is incorrectly predicted as negative (not belonging to the target class). A false negative rate is the ratio of false negatives to all actual positive cases. A low false negative rate means that most of the positive cases are correctly identified by the classifier.

For a diagnostic tool that can diagnose a particular disease so that individuals with the disease can receive treatment, it is of primary importance that it has a low false negative rate. This is because false negatives can have serious consequences for patients who have the disease but do not receive treatment, such as increased risk of mortality or complications. A low false negative rate can ensure that most patients who have the disease are diagnosed correctly and receive timely treatment.